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I truly felt like my entire brain had been reduced to a tiny pellet, almost like a pinball–with my skull as the pinball machine. I don't think someone should worry to much about substrates when selecting an antidepressant. The downside of taking anti-depressants is that the effect does not occur immediately. If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy.
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