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Zoloft (sertraline) may be taken with our without food and should be taken with water. Zoloft should not be stopped abruptly, withdrawal symptoms may occur. Zoloft works by elevating brain levels of serotonin, which is a natural substance that assists in maintaining mental balance. A search of prescribing information did not specifically list abnormal dreams as a side effect of zoloft. Zoloft is used for the treatment of depression, obsessive-compulsive disorder, and anxiety disorders. Zoloft should be taken with a full glass of water and may be taken with our without food.

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