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Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. Consistent with the terminal elimination half-life, there is an approximately two-fold accumulation up to steady-state concentrations, which are achieved after one week of once- daily dosing. Zoloft is one of the most popular medications in fighting depression and improving one's mood and outlook on life. Zoloft is the most prescribed antidepressant out there. Zoloft is also fast acting and can give results relatively quickly. Less serious and still concerning side effects associated with sertraline use include drowsiness, dizziness, tired feeling, mild nausea, stomach pain, upset stomach, constipation, dry mouth, changes in appetite or weight, sleep problems (insomnia), decreased sex drive, impotence or difficulty having an orgasm. Zoloft addiction can result when a user begins abusing the drug by crushing the pills and inhaling them or by swallowing several pills at once.

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